alexa Somatic generation of antibody diversity.
Engineering

Engineering

Innovative Energy & Research

Author(s): Tonegawa S

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Abstract In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
This article was published in Nature and referenced in Innovative Energy & Research

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