Author(s): Wu J, Pepe J, Rincn M
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Abstract It has been shown experimentally in cell suspensions that sonoporation could be used to deliver the anti-cancer drug Adriamycin hydrochloride (ADR) into Jurkat lymphocytes and that it could also be used to deliver goat anti-rabbit IgG and anti-mouse IgD, antibodies into human peripheral blood mononuclear cells (PBMC) and Jurkat lymphocytes. When ADR was delivered, the delivery efficiency reached 4.80+/-2.04\% and control baseline (no ultrasound and no ADR) was 0.17+/-0.14\%. When anti-rabbit IgD was delivered, the efficiencies were 34.90+/-1.80\% (control baseline was 1.33+/-0.31\%) and 32.50+/-4.36\% (control baseline was 1.66+/-0.06\%) respectively for Jurkat cells and PBMC. When goat anti-rabbit IgG was delivered, the efficiencies were 78.60+/-3.60\% (control baseline was 1.60+/-0.00\%) and 57.50+/-4.23\% (control baseline was 11.30+/-0.81\%) respectively for Jurkat cells and PBMC.
This article was published in Ultrasonics
and referenced in Journal of Nanomedicine & Nanotechnology