alexa Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Tran EE, Simmons JA, Bartesaghi A, Shoemaker CJ, Nelson E,

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Abstract The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
This article was published in J Virol and referenced in Journal of Molecular and Genetic Medicine

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