alexa Spectrophotometric determination of cephalexin in dosage forms with imidazole reagent.


Pharmaceutical Analytical Chemistry

Author(s): Alwarthan AA, Fattah SA, Zahran NM

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Abstract A simple spectrophotometric method is proposed for the determination of cephalexin. The method involves acetylation of cephalexin with acetic anhydride in aqueous solution at pH 11.5 to yield alpha-acetamidocephalexin and subsequent measurement at 335 nm of alpha-acetamidocephalexin mercuric mercaptide. The method characterizes a newly developed, sensitive procedure for the determination of cephalexin in different pharmaceutical preparations. The effect of several reaction conditions were investigated. Beer's law was obeyed over the concentration range 30-340 mug/ml. The results compare favourably with those obtained by the official B.P. 1980 method.
This article was published in Talanta and referenced in Pharmaceutical Analytical Chemistry

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