alexa Spectrophotometric Determination of Cilostazol in Tablet Dosage Form
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Pawan Kumar Basniwal, Vinesh Kumar, Prabhat Kumar, Shrivastava, Deepti Jain

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Purpose: To develop simple, rapid and selective spectrophoto metric methods for the determination of cilostazol in tablet dosage form. Methods: Cilostazol was dissolved in 50 % methanol and its a bsorbance was scanned by ultraviolet (UV) spectrophotometry. Both linear regression equa tion and standard absorptivity were calculated and both methods were validated as per ICH guidelines. Cilostazol was determined in tablet dosage form using these validated methods. Results: The λ max of cilostazol was 258.2 nm in 50 % methanol. Beer- Lambert’s law was obeyed in the concentration range of 0 – 25 μ g/ml and standard absorptivity was 420.2 dL.g -1 .cm -1 . The numerical values for all the validation parameters were withi n acceptable limits. The results of cilostazol tabl et determination by linear regression equation and sta ndard absorptivity methods indicate purity of 100.0 - 102.4 and 98.7 - 101.1 % with standard deviations o f 0.611 and 0.592, respectively. Comparing the methods at 99 % confidence limit, the F-test value was found to be 1.065. Conclusion: These validated methods may be useful for routine a nalysis of cilostazol as bulk drugs, in dosage forms as well as in dissolution studies in t he pharmaceutical industry.

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This article was published in Tropical Journal of Pharmaceutical Research and referenced in Journal of Chromatography & Separation Techniques

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