Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Pawar V T, Pishawikar S A, More H N

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An attempt has been made to develop a simple, economic, sensitive and reproducible spectrophotometric method for quantitative estimation of Aceclofenac and Paracetamol from bulk drug and in pharmaceutical formulations.The method employing Q absorbance ratio method is very simple method and can be employed for routine analysis of Aceclofenac (ACE) and Paracetamol (PARA). The proposed method for simultaneous estimation of Aceclofenac and Paracetamol utilizes the spectrum mode of analysis of Jasco V-530 spectrophotometer. The method utilizes 274 nm and 268 nm as an analytical wavelength for estimation of Aceclofenac and Paracetamol. Once the absorptivity values are determined very little time is required for analysis, as it would only require determination of absorbance’s of the sample solution at two selected wavelengths and few simple calculations. The accuracy of the method was determined by investigating the recovery of the two drugs using spiked concentrations of the standard drug. The results indicated excellent recoveries ranging from 100.49 to 101.33 % for the two drugs. Precision for tablet analysis was determined by analysis of tablets containing Aceclofenac and Paracetamol. Result of tablet analysis indicated that there was no interference of the common excipients used in the tablet formulation. Validation of this method is done as per ICHQ2B guidelines. The proposed method is highly sensitive and successfully applied for the analysis of Aceclofenac and Paracetamol in tablet formulation.

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This article was published in International Research Journal of Pharmacy and referenced in Journal of Chromatography & Separation Techniques

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