alexa SPECTROPHOTOMETRIC ESTIMATION OF ACECLOFENAC AND PARACETAMOL FROM TABLET DOSAGE FORM
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Pawar V T, Pishawikar S A, More H N

Abstract Share this page

An attempt has been made to develop a simple, economic, sensitive and reproducible spectrophotometric method for quantitative estimation of Aceclofenac and Paracetamol from bulk drug and in pharmaceutical formulations.The method employing Q absorbance ratio method is very simple method and can be employed for routine analysis of Aceclofenac (ACE) and Paracetamol (PARA). The proposed method for simultaneous estimation of Aceclofenac and Paracetamol utilizes the spectrum mode of analysis of Jasco V-530 spectrophotometer. The method utilizes 274 nm and 268 nm as an analytical wavelength for estimation of Aceclofenac and Paracetamol. Once the absorptivity values are determined very little time is required for analysis, as it would only require determination of absorbance’s of the sample solution at two selected wavelengths and few simple calculations. The accuracy of the method was determined by investigating the recovery of the two drugs using spiked concentrations of the standard drug. The results indicated excellent recoveries ranging from 100.49 to 101.33 % for the two drugs. Precision for tablet analysis was determined by analysis of tablets containing Aceclofenac and Paracetamol. Result of tablet analysis indicated that there was no interference of the common excipients used in the tablet formulation. Validation of this method is done as per ICHQ2B guidelines. The proposed method is highly sensitive and successfully applied for the analysis of Aceclofenac and Paracetamol in tablet formulation.

  • To read the full article Visit
  • Subscription
This article was published in International Research Journal of Pharmacy and referenced in Journal of Chromatography & Separation Techniques

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords