alexa Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Ramzia Ismail ElBagary, Ehab Farouk Elkady, Marwa Ahmed Hegazi, Nour Eldin Amin

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Accurate, precise and simple spectrophotometric methods have been developed and validated for the determination of paracetamol (PAR) and dantrolene sodium (DAS). Spectrophotometric methods including zero order, first derivative (1D) and derivative ratio methods (1DD) have been developed. The zero order spectrophotometric method was used for the determination of DAS in the range of 1-20 μg/mL by measuring the absorbance at 379 nm where PAR exhibits zero reading. 1D and 1DD methods were used for the determination of PAR in the range of 1.5-20.0 μg/mL by measuring the peaks amplitudes at 265.5 nm and 265.0 nm, respectively. The proposed methods were used to determine PAR in binary mixture with DAS in the laboratory prepared mixtures and in pharmaceutical dosage form. The results obtained were statistically evaluated and found to be accurate and precise and can be satisfactorily applied for the quality control analysis of the cited drugs.

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This article was published in European Journal of Chemistry and referenced in Journal of Chromatography & Separation Techniques

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