alexa Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Imaging & Dynamics

Author(s): Pan JW, Mason GF, Pohost GM, Hetherington HP

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Abstract The authors reported the development and implementation of a water-suppressed J-refocused coherence transfer sequence to observe glutamate in human brain at 4.1 T. The sequence is modeled for I2S2 and I2S2M spin systems analytically and plotted for a range of echo times. In this sequence, water suppression and refocusing of J-coupled resonances are achieved through a brief multiple quantum step without significant loss of signal. Phantom data are shown. Human brain spectroscopic imaging of glutamate, acquired with a total echo of 36 ms, demonstrates the application of the sequence to observe gray and white matter differences in glutamate content.
This article was published in Magn Reson Med and referenced in Journal of Molecular Imaging & Dynamics

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