Author(s): Kruger TF, Menkveld R, Stander FS, Lombard CJ, Van der Merwe JP,
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Abstract To determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program, the authors conducted a prospective study in women with bilateral tubal damage. Based on the percentage of morphologically normal spermatozoa, the patients were divided into four groups: group I, normal morphologic features between 0\% and 14\%; group II, 15\% to 30\%; group III, 31\% to 45\%; and group IV, 46\% to 60\%. One hundred ninety successful laparoscopic cycles were evaluated. In group I, 104 oocytes were obtained, of which 37\% fertilized, but no pregnancy resulted; in group II, 81\% of 324 oocytes were fertilized, with a pregnancy rate per embryo transfer (ET) of 22\%; in group III, 82\% of 309 oocytes were fertilized, with a 31\% pregnancy rate; and in group IV, 91\% of 69 oocytes were fertilized, with a pregnancy rate of 12\%. Probability models indicated that there was a clear threshold in normal sperm morphologic features at 14\%, with high fertilization and pregnancy rate in the groups with normal sperm morphologic features greater than 14\%.
This article was published in Fertil Steril
and referenced in Andrology-Open Access