alexa Split-skin graft in the management of diabetic foot ulcers.
Pharmaceutical Sciences

Pharmaceutical Sciences

Clinical Pharmacology & Biopharmaceutics

Author(s): Mahmoud SM, Mohamed AA, Mahdi SE, Ahmed ME

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Abstract OBJECTIVE: To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay. METHOD: In this prospective case-controlled study, 50 patients consented to skin grafting (graft group) and 50 preferred to be managed by conservative dressings (control group). Wound management in both groups was standardised with regard to the dressing materials (which comprised a multilayer dressing including paraffin gauze and diluted povidone-iodine soaked gauze), wound care and surgeon involvement. Graft take, ulcer recurrence rate and donor-site morbidity were assessed. Healing times and the length of hospital stay were compared between the two groups. RESULTS: A 100\% skin graft take was recorded in 84\% of the patients on the fifth postoperative day and in 62\% on weeks 3 and 8. All patients in the graft group healed completely, but 8\% had an ulcer recurrence and 4\% a superficial infection within the following year. The mean healing time and mean length of hospital stay were significantly less in the graft group compared with the control group (p<0.001), reflecting results of similar studies. CONCLUSION: Split-skin grafting is an effective method of managing diabetic foot ulcers as, compared with the conservative dressings used in this study, it reduced healing times and the length of hospital stay, while donor-site morbidity was minimal. This article was published in J Wound Care and referenced in Clinical Pharmacology & Biopharmaceutics

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