alexa Spontaneous regression of multiple pulmonary metastases after radiofrequency ablation of a single metastasis


Journal of Vaccines & Vaccination

Author(s): Rao P, Escudier B, de Baere T

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We report two cases of spontaneous regression of multiple pulmonary metastases occurring after radiofrequency ablation (RFA) of a single lung metastasis. To the best of our knowledge, these are the first such cases reported. These two patients presented with lung metastases progressive despite treatment with interleukin-2, interferon, or sorafenib but were safely ablated with percutaneous RFA under computed tomography guidance. Percutaneous RFA allowed control of the targeted tumors for >1 year. Distant lung metastases presented an objective response despite the fact that they received no targeted local treatment. Local ablative techniques, such as RFA, induce the release of tumor-degradation product, which is probably responsible for an immunologic reaction that is able to produce a response in distant tumors.

This article was published in Cardiovasc Intervent Radiol and referenced in Journal of Vaccines & Vaccination

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