alexa STABILITY-INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF FELODIPINE (A CALCIUM CHANNEL BLOCKER) IN TABLETS
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Manoj Kumar Vadlamudi, Sangeetha Dhanaraj

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A simple stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Felodipine in tablet dosage forms. Reversed-phase chromatography was performed on Shimadzu Model CBM-20A/20 Alite, using a mixture of tetra butyl ammonium hydrogen sulphate and acetonitrile (18:82, v/v) as mobile phase with a flow rate of 1.2 mL/min. Detection was carried at 237 nm. Linearity was observed over the concentration range of 0.1–350 μg/mL (R2 = 0.9997) with regression equation y = 62606 x + 9590.9. Felodipine was subjected to stress conditions (acidic, alkaline, oxidation and thermal degradation) and validated as per ICH guidelines.

This article was published in Indo American Journal of Pharmaceutical Research and referenced in Journal of Bioequivalence & Bioavailability

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