alexa Stabilizing effect of magnesium chloride and sucrose on Sabin live polio vaccine.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Mirchamsy H, Shafyi A, Mahinpour M, Nazari P

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Abstract A trivalent vaccine was stabilized with (a) 70\% sucrose, (b) MgCl2 1M, and (c) 35\% sucrose plus MgCl2 1/2M. A portion of each batch was kept at +4 degrees C and 22-25 degrees C. No change in titre for all 3 preparations was recorded after 9 weeks storage at +4 degrees C. While the potency of vaccines containing MgCl2 alone or mixed with sucrose and kept at +25-28 degrees C for 5 weeks was not altered, the vaccine containing only sucrose was less stable, and a drop of titre was noticed after 2 weeks of storage at +22-25 degrees C. Monovalent polio vaccines were also stabilized as above and kept at +4 degrees C or at -20 degrees C. It was found that regardless of the type of stabilizer used, 82 to 97 per cent of potency was retained after 9 months of storage at +4 degrees C or at -20 degrees C.
This article was published in Dev Biol Stand and referenced in Journal of Vaccines & Vaccination

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