alexa Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Health & Medical Informatics

Author(s): Chmait RH, Kontopoulos EV, Korst LM, Llanes A, Petisco I, , Chmait RH, Kontopoulos EV, Korst LM, Llanes A, Petisco I, , Chmait RH, Kontopoulos EV, Korst LM, Llanes A, Petisco I, , Chmait RH, Kontopoulos EV, Korst LM, Llanes A, Petisco I,

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Abstract OBJECTIVE: We sought to describe stage-specific perinatal outcomes after selective laser photocoagulation of communicating vessels (SLPCV) for twin-twin transfusion syndrome. STUDY DESIGN: Patients with twin-twin transfusion syndrome underwent SLPCV preferentially using sequential vs standard laser technique. Patient characteristics and outcome data were examined by Quintero stage. RESULTS: Of 682 consecutive women studied, the Quintero stage distribution was: 114 stage I (17\%), 177 stage II (26\%), 328 stage III (48\%), and 63 stage IV (9\%). Perinatal survival of at least 1 twin did not differ according to stage (I-92\%, II-93\%, III-88\%, IV-92\%; P = .30). However, dual twin survival differed by stage (I-79\%, II-76\%, III-59\%, IV-68\%; P < .01), primarily because stage III pregnancies were associated with decreased donor twin survival (P < .01). Sequential SLPCV was associated with improved donor survival, independent of stage (odds ratio, 1.67; 95\% confidence interval, 1.16-2.40; P < .01). CONCLUSION: Stage-specific perinatal outcomes after laser therapy may assist physicians in patient counseling and in planning future studies. Copyright © 2011 Mosby, Inc. All rights reserved. This article was published in Am J Obstet Gynecol and referenced in Journal of Health & Medical Informatics

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