alexa Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Uckun FM, Pendergrass S, Venkatachalam TK, Qazi S, Richman D, Uckun FM, Pendergrass S, Venkatachalam TK, Qazi S, Richman D

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Abstract We report the antiretroviral activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates. STAMP inhibited each one of nine clinical HIV-1 isolates of non-B envelope subtype and 20 genotypically and phenotypically nucleoside analog reverse transcriptase inhibitor-resistant HIV-1 isolates at subnanomolar to low-nanomolar concentrations.
This article was published in Antimicrob Agents Chemother and referenced in Journal of AIDS & Clinical Research

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