alexa Statin Reduces C-Reactive Protein and Interleukin-6 in Normocholesterolemic Patients with Acute Coronary Syndrome


Journal of Cytokine Biology

Author(s): Ok Young Park, Soo Hang Kim, Young Keun Ahn, Nam Sik Yun, Ju Han Kim

Abstract Share this page

Many evidences suggest that atherosclerosis is an inflammatory
disease and inflammatory markers can
be an important prognostic factors in acute coronary syndrome.
Hydroxymethylglutaryl (HMG-CoA) redu-
ctase inhibitors (statins) have been shown anti-inflammatory pr
operty that are independent of lipid-lowering
effects. We evaluated the effects of 2-month treatment with sim
vastatin (40 mg/d, n=20) on plasma levels
of circulating high-sensitivity C-reactive protein (hsCRP), inf
lammatory cytokines [tumor necrosis factor
, interleukin (IL)-1
, IL-6], and adhesion molecules [p-selectin and monocyte chemot
actic peptide
(MCP)-1] with placebo group (n=20) in 40 normocholesterolemic p
atients (LDL
130 mg/dl) with acute
coronary syndrome. Simvastatin therapy significantly reduced pl
asma levels of total cholesterol and
LDL-cholesterol (p=0.05, p=0.02, respectively) compared with pl
acebo group. Simvastatin therapy also
significantly reduced plasma levels of hsCRP and IL-6 (p=0.03,
p=0.03, respectively) compared with
placebo group. But, the reduction of hsCRP and IL-6 levels with
simvastatin was unrelated to the degree
of LDL-cholesterol's reduction. The effect of simvastatin on th
e reduction of hsCRP and IL-6, but not on
the other inflammatory cytokines and adhesion molecules, have p
otential implications in the management
of acute coronary syndrome with normocholesterolemia.


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This article was published in Chonnam Medical Journal and referenced in Journal of Cytokine Biology

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