Author(s): Boza A, De la Cruz Y, Jordn G, JureguiHaza U, Alemn A,
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Abstract The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90\% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 microliters, and CE = 0).
This article was published in Drug Dev Ind Pharm
and referenced in Journal of Addiction Research & Therapy