alexa Stem Cell Transplant in Severe Glanzmann Thrombasthenia in an Adult Patient.
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Ramzi M, Dehghani M, Haghighat S, Nejad HH

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Abstract Glanzmann thrombasthenia is an inherited autosomal recessive disorder characterized by normal platelet count but lack of platelet aggregation due to absence of platelet glycoprotein IIb/IIIa. The disease usually is associated with mild bleeding, but severe fatal hemorrhage may occur. Allogeneic stem cell transplant is the only curative method of treatment. A literature search showed 18 previously reported cases of Glanzmann thrombasthenia treated with allogeneic hematopoietic stem cell transplant. We report an 18-year-old woman with severe Glanzmann thrombasthenia who was treated with allogeneic hematopoietic stem cell transplant from her sister. After 24-month follow-up, the patient was well, had no bleeding tendency, and had mild chronic skin graft-versus-host disease. This article was published in Exp Clin Transplant and referenced in Journal of Clinical Case Reports

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