alexa Stent-induced pancreatic ductal and parenchymal changes: correlation of endoscopic ultrasound with ERCP.
Diabetes & Endocrinology

Diabetes & Endocrinology

Pancreatic Disorders & Therapy

Author(s): Sherman S, Hawes RH, Savides TJ, Gress FG, Ikenberry SO,

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Abstract BACKGROUND: Polyethylene pancreatic duct stents induce morphologic changes of the pancreatic duct in the majority of patients. This study was undertaken to determine if parenchymal abnormalities are present in patients undergoing short-term pancreatic duct stenting and to correlate these findings with the pancreatogram obtained at stent removal. METHODS: Twenty-five patients underwent pancreatic duct stenting and had an endoscopic ultrasound evaluation of the pancreas at stent removal. The pancreatograms were evaluated at stent removal for ductal irregularity, narrowing, and side branch changes. Endoscopic ultrasound was used to assess for differences in the echo characteristics of the pancreatic parenchyma around the stent compared with the rest of the gland. RESULTS: Of the 16 patients evaluated by ERCP at stent removal, 9 (56\%) had 1 or more new ductographic changes. Endoscopic ultrasound identified parenchymal changes in the stented region in 17 of 25 patients (68\%). Four patients who had parenchymal changes in the stented region on endoscopic ultrasound at stent removal had a follow-up study at a mean time of 16 months. Two patients had (new) changes suggestive of focal chronic pancreatitis in the stented region. CONCLUSION: Short-term pancreatic duct stenting induced both ductal and parenchymal changes in more than 50\% of patients. Chronic pancreatitis may be a consequence of pancreatic duct stenting.
This article was published in Gastrointest Endosc and referenced in Pancreatic Disorders & Therapy

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