alexa Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
Cardiology

Cardiology

Atherosclerosis: Open Access

Author(s): Onishi H, Shirato H, Nagata Y, Hiraoka M, Fujino M,

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Abstract PURPOSE: To review treatment outcomes for stereotactic body radiotherapy (SBRT) in medically operable patients with Stage I non-small-cell lung cancer (NSCLC), using a Japanese multi-institutional database. PATIENTS AND METHODS: Between 1995 and 2004, a total of 87 patients with Stage I NSCLC (median age, 74 years; T1N0M0, n=65; T2N0M0, n=22) who were medically operable but refused surgery were treated using SBRT alone in 14 institutions. Stereotactic three-dimensional treatment was performed using noncoplanar dynamic arcs or multiple static ports. Total dose was 45-72.5 Gy at the isocenter, administered in 3-10 fractions. Median calculated biological effective dose was 116 Gy (range, 100-141 Gy). Data were collected and analyzed retrospectively. RESULTS: During follow-up (median, 55 months), cumulative local control rates for T1 and T2 tumors at 5 years after SBRT were 92\% and 73\%, respectively. Pulmonary complications above Grade 2 arose in 1 patient (1.1\%). Five-year overall survival rates for Stage IA and IB subgroups were 72\% and 62\%, respectively. One patient who developed local recurrences safely underwent salvage surgery. CONCLUSION: Stereotactic body radiotherapy is safe and promising as a radical treatment for operable Stage I NSCLC. The survival rate for SBRT is potentially comparable to that for surgery. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Int J Radiat Oncol Biol Phys and referenced in Atherosclerosis: Open Access

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