Author(s): Dutta NK, Pinn ML, Karakousis PC
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Abstract We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
This article was published in Antimicrob Agents Chemother
and referenced in Biochemistry & Pharmacology: Open Access