Author(s): Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G,
Abstract Share this page
Abstract Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
This article was published in Science
and referenced in Journal of Clinical & Cellular Immunology