Author(s): Bazhenova EN, Saris NE, Zvyagilskaya RA
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Abstract The Ca2+ uptake by mitochondria from the yeast Endomyces magnusii has earlier been found to be driven by the membrane potential and to be stimulated by spermine. It thus functions in a similar fashion as the animal mitochondrial calcium uniporter. Here, it is shown that the uptake is stimulated, i.e., Ca2+ can be accumulated from lower [Ca2+], under hypotonic conditions. Ruthenium Red, an inhibitor of the animal uniporter, under certain conditions, stimulates the yeast uniporter. The mechanism of the stimulation by hypotonicity and Ruthenium Red is discussed. Copyright 1998 Elsevier Science B.V.
This article was published in Biochim Biophys Acta
and referenced in Biochemistry & Analytical Biochemistry