Author(s): Yunos DM, Ahmad Z, Salih V, Boccaccini AR
Abstract Share this page
Abstract This work focuses on designing bilayered constructs by combining electrospun poly-DL-Lactide (PDLLA) fibers and Bioglass┬«-derived scaffolds for development of osteochondral tissue replacement materials. Electrospinning was carried out using a solution of 5 wt/v\% PDLLA in dimethyl carbonate. The PDLLA layer thickness increased from 2 to 150 ┬Ám with varying electrospinning time. Bioactivity studies in simulated body fluid showed that HA mineralization decreased as the thickness of the PDLLA layer increased. A preliminary in vitro study using chondrocyte cells (ATDC5) showed that cells attached, proliferated and migrated into the fibrous network, confirming the potential applicability of the bilayered scaffolds in osteochondral defect regeneration.
This article was published in J Biomater Appl
and referenced in Journal of Tissue Science & Engineering