alexa Structural and functional characterization of the glycan antigens involved in immunobiology of Q fever.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Vadovic P, Slaba K, Fodorova M, Skultety L, Toman R

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Abstract Coxiella burnetii is the causative agent of Q fever. The bacterium is extremely infectious and is classified as a category biological weapon. A lipopolysaccharide I (LPS I) belongs to the main components of the C. burnetii outer membrane and its structure-function relationship studies are of potential interest. Size-exclusion chromatography revealed noticeable differences in distribution and chemical composition of the O-polysaccharide chains in LPS I. It is likely that C. burnetii is capable of synthesizing chemically distinct subclasses of O-specific polysaccharide molecules differing in their antigenic reactivities. Methylation-linkage analysis indicated the presence of terminal virenose (Vir), dihydrohydroxystreptose (Strep), and mannose (Man), 4-substituted Vir, and 4-substituted Man in the O-specific chain. Serological data indicate that Vir and Strep might be involved in the immunobiology of Q fever. This article was published in Ann N Y Acad Sci and referenced in Journal of Bioterrorism & Biodefense

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