alexa Structural barrier principle for growth factor-based articular cartilage repair.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Tissue Science & Engineering

Author(s): Hunziker EB, Driesang IM, Saager C

Abstract Share this page

Abstract A growth factor-based strategy recently has been shown to induce the intrinsic repair of partial-thickness articular cartilage lesions, thereby obviating the need for transplanting cells or tissue. It was the purpose of the current study to ascertain whether this principle could be applied to full-thickness articular cartilage defects created in adult rabbits and mature miniature pigs. The transforming growth factor-beta1 contained within the authors' chondrogenic matrix-complex proved to be potent in its osteogenic capacity when liberated into the bone compartment of such lesions, inducing the rapid upgrowth of osseous tissue and vascular buds into the cartilage compartment. This is an unwanted response that must be prevented. A cell and blood vessel-excluding membrane (Millipore in rabbits and Goretex in miniature pigs) was inserted at the interface between cartilage and bone compartments, both of which were filled at the appropriate juncture with the chondrogenic matrix-complex. These structural barriers were effective in obstructing the up-growth of blood vessels into the cartilage compartment and in preventing the osteogenic tissue differentiation attributable to the presence of a vasculature.
This article was published in Clin Orthop Relat Res and referenced in Journal of Tissue Science & Engineering

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 6th International Conference on Tissue Engineering and Regenerative Medicine
    August 23-24 , 2017 San Francisco, California ,USA
  • 8th International Conference on Tissue Science and Regenarative Medicine
    September 11-12, 2017 Singapore City, singapore
  • 9th Annual Conference on Stem Cell and Regenerative Medicine
    Sep 25-26, 2017 Berlin, Germany
  • 10th World Congress on Stem Cell and Biobanking
    October 23-24, 2017 Osaka, Japan

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version