Author(s): Sassa H, Kogure K, Takaishi Y, Terada H
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Abstract The structural basis of the potent inhibitory effect of the triterpene celastrol on lipid peroxidation of rat liver mitochondria initiated by adenosine 5'-diphosphate (ADP) and Fe2+ was studied in comparison with the effects of its analogs, pristimerin and acetylcelastrol. The dienone-phenol moiety and the anionic carboxyl group of celastrol were concluded to be important for their antiperoxidative action: The former moiety directly scavenges radicals and the latter donates the membrane with a negative surface charge, making it more resistant to peroxidation. Celastrol is suggested to inhibit the peroxidation of the outer and inner mitochondrial membrane by direct radical scavenging, and also to prevent the attack of oxygen radicals on the inner membrane by increasing its negative surface charge.
This article was published in Free Radic Biol Med
and referenced in Journal of Cytology & Histology
- Ji-Zhong Bai
Astrocytic contribution to deficient Ca2+ signalling and oxidative stress mediated by TRPV4 channels in A40-induced hippocampal cell death
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