alexa Structural Decoding of the Netrin-1 UNC5 Interaction and its Therapeutical Implications in Cancers.
Surgery

Surgery

Journal of Vascular Medicine & Surgery

Author(s): Grandin M, Meier M, Delcros JG, Nikodemus D, Reuten R,

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Abstract Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate. Copyright © 2016 Elsevier Inc. All rights reserved. This article was published in Cancer Cell and referenced in Journal of Vascular Medicine & Surgery

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