Author(s): Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, , Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K,
Abstract Share this page
Abstract We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.
This article was published in Bioorg Med Chem Lett
and referenced in Journal of Cancer Science & Therapy