alexa Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, , Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K,

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Abstract We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors. This article was published in Bioorg Med Chem Lett and referenced in Journal of Cancer Science & Therapy

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