alexa Structural mechanism of the recovery stroke in the myosin molecular motor.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Fischer S, Windshgel B, Horak D, Holmes KC, Smith JC

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Abstract The power stroke pulling myosin along actin filaments during muscle contraction is achieved by a large rotation ( approximately 60 degrees ) of the myosin lever arm after ATP hydrolysis. Upon binding the next ATP, myosin dissociates from actin, but its ATPase site is still partially open and catalytically off. Myosin must then close and activate its ATPase site while returning the lever arm for the next power stroke. A mechanism for this coupling between the ATPase site and the distant lever arm is determined here by generating a continuous series of optimized intermediates between the crystallographic end-states of the recovery stroke. This yields a detailed structural model for communication between the catalytic and the force-generating regions that is consistent with experimental observations. The coupling is achieved by an amplifying cascade of conformational changes along the relay helix lying between the ATPase and the domain carrying the lever arm.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Nanomedicine & Nanotechnology

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