alexa Structure of the glycoprotein gene in rabies virus
Veterinary Sciences

Veterinary Sciences

Research & Reviews: Journal of Veterinary Sciences

Author(s): Anilionis A

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Rabies virus, a rhabdovirus, has a single (non-segmented) negative-strand RNA genome which is transcribed on infection to produce five polyadenylated complementary monocistronic mRNA species. Each of the virus-specific mRNAs representing a structural gene of the rabies virus genome1 codes for a virion structural protein which corresponds in size to the apparent coding capacity of its mRNA2,3. The glycoprotein gene codes for a membrane-associated molecule which forms spike-like projections on the surface of mature rabies virions and is responsible for the induction and binding of virus-neutralizing antibodies to the virus4-6. To define the antigenic and immunogenic properties of rabies virus glycoprotein, we have cloned a cDNA copy of its mRNA sequence into pBR322 (ref. 7). Here we describe the characterization of the cDNA sequence, which has allowed us to predict several features of the glycoprotein from the deduced amino acid sequence.

This article was published in Nature and referenced in Research & Reviews: Journal of Veterinary Sciences

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