alexa Structure of the glycoprotein gene in rabies virus
Veterinary Sciences

Veterinary Sciences

Research & Reviews: Journal of Veterinary Sciences

Author(s): Anilionis A

Abstract Share this page

Rabies virus, a rhabdovirus, has a single (non-segmented) negative-strand RNA genome which is transcribed on infection to produce five polyadenylated complementary monocistronic mRNA species. Each of the virus-specific mRNAs representing a structural gene of the rabies virus genome1 codes for a virion structural protein which corresponds in size to the apparent coding capacity of its mRNA2,3. The glycoprotein gene codes for a membrane-associated molecule which forms spike-like projections on the surface of mature rabies virions and is responsible for the induction and binding of virus-neutralizing antibodies to the virus4-6. To define the antigenic and immunogenic properties of rabies virus glycoprotein, we have cloned a cDNA copy of its mRNA sequence into pBR322 (ref. 7). Here we describe the characterization of the cDNA sequence, which has allowed us to predict several features of the glycoprotein from the deduced amino acid sequence.

This article was published in Nature and referenced in Research & Reviews: Journal of Veterinary Sciences

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version