alexa Structure-based virtual screening of chemical libraries for drug discovery.
Medicine

Medicine

Drug Designing: Open Access

Author(s): Ghosh S, Nie A, An J, Huang Z

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Abstract One of the main goals in drug discovery is to identify new chemical entities that have a high likelihood of binding to the target protein to elicit the desired biological response. To this end, virtual screening is being increasingly used as a complement to high-throughput screening to improve the speed and efficiency of the drug discovery and development process. The availability of inexpensive high-performance computing platforms in recent years has transformed this field into one that is highly diverse and rapidly evolving, where large chemical databases have been successfully screened to identify hits for a wide range of targets such as Bcl-2 family proteins, G protein-coupled receptors, kinases, metalloproteins, nuclear hormone receptors, proteases and many more. This article was published in Curr Opin Chem Biol and referenced in Drug Designing: Open Access

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