alexa Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Iijima I, Minamikawa J, Jacobson AE, Brossi A, Rice KC

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Abstract (+)-Naloxone was prepared in 26\% overall yield in eight steps from (+)-7-bromodihydrocodeinone dimethyl ketal by a synthesis which excluded enantiomeric contamination. (+)-Naloxone was examined in three assay systems and found to have no more than 1/1000(-1)/10 000th the activity of (-)-naloxone; it can, thus, serve to test the stereospecificity of the biochemical and pharmacological actions of (-)-naloxone.

This article was published in J Med Chem and referenced in Journal of Glycomics & Lipidomics

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