Author(s): Sharma S, Lakshmi KS, Patidar A, Chaudhary A, Dhaker S
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Abstract OBJECTIVES: The purpose of the present study was to investigate the anti-inflammatory properties of aqueous extract of the leaves of H. integrifolia, Planch. MATERIALS AND METHODS: The hind paw edema was produced in rats by subplanter injection of carageenan. The aqueous extract of H. integrifolia, Planch. (AHI) at dose (250 and 500 mg/kg p.o) was given to observe \% inhibition of paw edema which were comparable with indomethacin (10 mg/kg p.o) used as a reference drug. RESULTS: The extract administered orally at doses of 250 and 500 mglkg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formation CONCLUSIONS: A significant \% inhibition of paw edema by the aqueous extract of leaves of H. integrifolia, Planch. and its almost nearby same \% inhibition with indomethacin suggest its usefulness as an anti-inflammatory agent.
This article was published in Indian J Pharmacol
and referenced in Journal of Addiction Research & Therapy