alexa Studies on the interaction between chromium(VI) and human serum albumin: spectroscopic approach.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Zhang GC, Xu JY, Wang YQ

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Abstract The interaction between Cr(2)O(7)(2-) and human serum albumin (HSA) was investigated using fluorescence, UV/vis, FT-IR, CD spectroscopy, and molecular modeling method. The experimental results showed that the fluorescence quenching of HSA by Cr(2)O(7)(2-) is a result of the formation of HSA-chromium(VI) complex; static quenching was confirmed to result in the fluorescence quenching. The corresponding thermodynamic parameters showed that the process of binding Cr(2)O(7)(2-) on HSA was a spontaneous molecular interaction procedure. Ionic, H-bonds and van der Waals interactions play a major role in stabilizing the complex. The Cr(2)O(7)(2-) altered the environments of Trp and Tyr residues in HSA. Copyright © 2011 Elsevier B.V. All rights reserved. This article was published in Spectrochim Acta A Mol Biomol Spectrosc and referenced in Medicinal Chemistry

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