alexa Studies towards the conception of new selective PPARbeta delta ligands.
Diabetes & Endocrinology

Diabetes & Endocrinology

Endocrinology & Metabolic Syndrome

Author(s): Bassne CE, Suzenet F, Hennuyer N, Staels B, Caignard DH,

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Abstract In order to define new PPARbeta/delta ligands, SAR study on the selective PPARbeta/delta activator L-165,041 led to the identification of one key functional group for selective PPARbeta/delta activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARbeta/delta ligand GW501516, the conception of new ligands showing good affinity for PPARbeta/delta is reported. Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARbeta/delta subtype selectivity. This article was published in Bioorg Med Chem Lett and referenced in Endocrinology & Metabolic Syndrome

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