alexa Study of Antihypertensive activity of Aerial parts of Passiflorafoetida Linn

Research & Reviews: Research Journal of Biology

Author(s): Ranganatha N, DrIJKuppast, Mr T Veershekar

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Hypertension is one of the leading causes of disability, mortality, and morbality along the populance. Passiflora foetida Linn. is an Indian medicinal plant which belongs to the family Passifloraceae. The plant has been reported to contain alkaloids and flavonoids. Hence the present study has been designed to evaluate the anti-hypertensive activity of ethanol, petroleum ether and ethyl acetate extracts of Passiflora foetida. The method of “up and down” (OECD Guideline No. 425) of CPCSEA was adopted for acute toxicity studies. The anti-hypertensive activity was carried out by measuring systolic and diastolic blood pressure in awaked animals by the non-invasive blood pressure module. Hypertension was induced by administering 8% salt (NaCl) solution for two weeks. Amlodipine (5 mg/kg) was used as a standard drug. In the present study ethyl acetate extract (300mg/ml) of Passiflora foetida has been shown significant antihypertensive activity. The anti-hypertensive effect produced by ethyl acetate extract of P. foetida may be due the activation of NO-dependent vasodilation and also due to the presence of flavonoids in the ethyl acetate extract. Hence it can be concluded that the ethyl acetate extract of Passiflora foetida Linn. has the potential to become a good anti-hypertensive drug. Further studies are needed to know the exact mechanism of action

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This article was published in An International Research Journal of Pharmacy and Plant Science and referenced in Research & Reviews: Research Journal of Biology

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