Author(s): Miarro M, GarcaMontoya E, SuNegre JM, Tic JR
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Abstract The study of formulation parameters in hydrophilic matrices of metoprolol tartrate by 2(3) factorial design wass made. We compared the dissolution profiles of two hydrophilic polymers (hydroxypropylmethylcellulose and hydroxyethylcellulose) at high and low concentrations and in the presence or absence of an insoluble excipient (calcium hydrogen phosphate dihydrate). The results showed that the presence of an insoluble excipient influenced almost all of the dissolution parameters.
This article was published in Drug Dev Ind Pharm
and referenced in Intellectual Property Rights: Open Access