alexa [Study of gene polymorphism responsible for metabolism of proton pump inhibitors in children with H. pylori infection: is there a correlation with efficacy of eradication treatment?].
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacogenomics & Pharmacoproteomics

Author(s): Nizhevich AA, Iunusbaev BB, Tugunov MM, Tsiglintseva NP, Nasretdinova EK

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Abstract THE AIM of this study was to determine the effects of CYP2C19 polymorphism on H. pylori eradication in pediatric population in the Republic of Bashkortostan. METHODS: Fifty-nine children were entered into the study (age range: 12 to 17; 22 female). All the patients were infected with H. pylori and received the combination of omeprazole (1 mg/kg/day), furazolidone (10 mg/kg/day) and amoxicilline (25 mg/kg/day) or clarithromycin (7.5 mg/kg/day) for 10 days. The participants were classified into 3 groups according to CYP2C19 genotype; rapid metabolizers (RM) (54.2\%), intermediate metabolizers (IM) (35.6\%) and poor metabolizers (PM) (10.2\%). H. pylori infection status was assessed before and after the treatment. RESULTS: The eradication rate was 65.6\% for RM, 71.4\% for IM, and 83.3\% for PM. CONCLUSION: The present study confirmed the low eradication rate for RM and for the IM groups. Alternative regimens expected to be with a higher eradication rate should be recommended (rabeprazole-based treatment).
This article was published in Eksp Klin Gastroenterol and referenced in Journal of Pharmacogenomics & Pharmacoproteomics

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