alexa Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy.


Lupus: Open Access

Author(s): Reed BR, Huff JC, Jones SK, Orton PW, Lee LA

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Photosensitive eruptions with clinical and histologic features of subacute cutaneous lupus erythematosus and antibodies to SS-A(Ro) antigen occurred in five patients taking hydrochlorothiazide. After drug therapy was discontinued, the eruptions cleared. In one patient anti-SS-A antibodies disappeared after discontinuation of thiazide, and in another rechallenge with hydrochlorothiazide produced an acute dermatitis with a photodistribution. These eruptions may represent a new type of photosensitive drug reaction in which the photoactive drug may be synergistic with anti-SS-A antibody in producing cutaneous lesions of photosensitive subacute cutaneous lupus erythematosus.

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This article was published in Ann Intern Med and referenced in Lupus: Open Access

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