alexa Sub-chronic toxicity study of a novel herbal-based formulation (Semelil) on dogs
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Farzamfar B, Abdollahi M, Kaabinejadian S, Heshmat R, Shahhosseiny MH

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Semelil (ANGIPARSTM), a novel herbal-based compound containing extract of Melilotus officinalis, was formulated for treatment of chronic wounds, especially diabetic foot ulcer. The purpose of this study was to investigate safety and toxicity effects of intramuscular administration of Semelil in dogs. Preliminary one-month study with Semelil was performed on 8 male and female dogs divided into 2 groups, test and control, four animals each. Semelil was administered intramuscularlyat a dose of 0.07 ml/kg body wt. once a day to the animals of the test group, while the control group received sterile saline. During experiments, general state of the animals including the dynamics of body weight changes, appetite, motor activity and behavior, hair condition, ECG parameters, rectal temperature of animals and data of hematological and biochemical tests were monitored for signs of toxicity and side-effects. Finally, morphology and histology analyses were performed using standard methods. No adverse health or toxicity effects were observed through the course of the study. No damaging consequences of Semelil injections on the functional state of main organs of the experimental animals were found. This observation gave a good evidence of a favorable safety profile compatible with potential therapeutic use of Semelil.

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This article was published in DARU Journal of Pharmaceutical Sciences and referenced in Journal of Clinical & Experimental Pathology

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