alexa Subjective effects of oral caffeine in formerly cocaine-dependent humans.


Journal of Addiction Research & Therapy

Author(s): Liguori A, Hughes JR, Goldberg K, Callas P

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Abstract Eleven formerly cocaine-dependent (FCD) adults (mean 4 years in recovery) and 11 with no substance dependence history (ND) drank one cup of coffee (caffeine content 0, 50, or 100 mg) per hour for 5 h (for a total of 0, 250, or 500 mg caffeine) in a double-blind, randomized crossover procedure. Participants completed self-report scales before the first cup and 50 min after each cup. Caffeine did not increase cocaine-like effect or desire-for-cocaine ratings among the FCD subjects. Ratings of 'jittery' (P < 0.05) and 'anxious/tense/nervous' (P < 0.10) increased more with caffeine in the FCD group than among ND subjects. Self-report measures of caffeine reinforcement did not differ between FCD and ND groups. These results suggest that, among FCD adults, (a) caffeine does not produce cocaine-like effects, (b) caffeine reinforcement is neither greater nor lesser than that among ND adults, and (c) chronic cocaine use may induce sensitization to some effects of stimulants.
This article was published in Drug Alcohol Depend and referenced in Journal of Addiction Research & Therapy

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