Author(s): Bastuji H, Jouvet M
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Abstract 1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83\% of 18 hypersomniac subjects and 71\% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for at least 3 years in some patients, produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.
This article was published in Prog Neuropsychopharmacol Biol Psychiatry
and referenced in Journal of Bioequivalence & Bioavailability