Author(s): Rosenbaum JT, Simpson J, Neuwelt CM
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Abstract BACKGROUND: Optic neuropathy is a rare manifestation of systemic lupus erythematosus (SLE). In a previous series most patients with optic neuropathy in association with SLE had a final visual acuity of 20/200 or less despite corticosteroid therapy. METHODS: Three patients (five affected eyes) with severe retrobulbar optic neuropathy in association with SLE were treated promptly with intravenous cyclophosphamide and corticosteroids. RESULTS: All patients recovered excellent visual acuity. CONCLUSION: Although optic neuropathy in association with SLE might have several different aetiologies, intravenous cyclophosphamide should be strongly considered as a therapeutic alternative.
This article was published in Br J Ophthalmol
and referenced in Journal of Clinical & Cellular Immunology