alexa Suicidal behaviour in youths with depression treated with new-generation antidepressants: meta-analysis.


Journal of Psychology & Psychotherapy

Author(s): Dubicka B, Hadley S, Roberts C

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Abstract BACKGROUND: Concern exists that antidepressants can cause suicidality in youths with depression. AIMS: To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants. METHOD: A meta-analysis was carried out to calculate odds ratios for the combined data. RESULTS: Self-harm or suicide-related events occurred in 71 of 1487 (4.8\%) of depressed youths treated with antidepressants v. 38 of 1254 (3.0\%) of those given placebo (fixed effects odds ratio 1.70, 95\% CI 1.13-2.54, P=0.01). There was a trend for individual suicidal thoughts, attempts and self-harm to occur more often in youths taking antidepressants than in those given placebo, but none of these differences was statistically significant. CONCLUSIONS: Antidepressants may cause a small short-term risk of self-harm or suicidal events in children and adolescents with major depressive disorder. This article was published in Br J Psychiatry and referenced in Journal of Psychology & Psychotherapy

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