Author(s): Mller S, Hoege C, Pyrowolakis G, Jentsch S
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Abstract Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.
This article was published in Nat Rev Mol Cell Biol
and referenced in Journal of Proteomics & Bioinformatics