alexa Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Ndhlovu LC, Chapman JM, Jha AR, SnyderCappione JE, Pagn M, , Ndhlovu LC, Chapman JM, Jha AR, SnyderCappione JE, Pagn M,

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Abstract IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.
This article was published in AIDS and referenced in Journal of AIDS & Clinical Research

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