Author(s): Ndhlovu LC, Chapman JM, Jha AR, SnyderCappione JE, Pagn M, , Ndhlovu LC, Chapman JM, Jha AR, SnyderCappione JE, Pagn M,
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Abstract IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.
This article was published in AIDS
and referenced in Journal of AIDS & Clinical Research