alexa [Survey on examinations for diagnosis of bone marrow failure in Japan: a report from the Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes].


Biochemistry & Physiology: Open Access

Author(s): Araseki K, Matsuda A, Tohyama K, Ishikawa T, Kawabata H,

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Abstract Using a registration sheet of a prospective registration system for aplastic anemia (AA)/myelodysplastic syndromes (MDS), by the National Research Group on Idiopathic Bone Marrow Failure Syndromes, Japan, we carried out a survey on examinations for diagnosis of bone marrow failure. Bone marrow trephine biopsy was performed in 66 of 105 cases (63\%) [Original diagnosis: AA 51 cases (80\%), MDS 12 (32\%), undiagnosable 3 (75\%)]. Bone marrow aspiration was performed in all cases, and aspiration was performed at least twice in 36 cases (34\%). The first-line anatomic site for bone marrow aspiration was the posterior iliac crest (62\%). Cytogenetic examination was performed in 93\%. The concordance rate between the original and the central review diagnosis was 93\% among the studied cases: AA, Idiopathic cytopenia of undetermined significance (ICUS) and MDS in total. Flow cytometry analysis to detect paroxysmal nocturnal hemoglobinuria (PNH)-type blood cells was performed in 32\%.
This article was published in Rinsho Ketsueki and referenced in Biochemistry & Physiology: Open Access

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