Author(s): International Early Lung Ca, Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW,
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Abstract BACKGROUND: The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown. METHODS: In a large collaborative study, we screened 31,567 asymptomatic persons at risk for lung cancer using low-dose CT from 1993 through 2005, and from 1994 through 2005, 27,456 repeated screenings were performed 7 to 18 months after the previous screening. We estimated the 10-year lung-cancer-specific survival rate among participants with clinical stage I lung cancer that was detected on CT screening and diagnosed by biopsy, regardless of the type of treatment received, and among those who underwent surgical resection of clinical stage I cancer within 1 month. A pathology panel reviewed the surgical specimens obtained from participants who underwent resection. RESULTS: Screening resulted in a diagnosis of lung cancer in 484 participants. Of these participants, 412 (85\%) had clinical stage I lung cancer, and the estimated 10-year survival rate was 88\% in this subgroup (95\% confidence interval [CI], 84 to 91). Among the 302 participants with clinical stage I cancer who underwent surgical resection within 1 month after diagnosis, the survival rate was 92\% (95\% CI, 88 to 95). The 8 participants with clinical stage I cancer who did not receive treatment died within 5 years after diagnosis. CONCLUSIONS: Annual spiral CT screening can detect lung cancer that is curable. Copyright 2006 Massachusetts Medical Society.
This article was published in N Engl J Med
and referenced in Journal of Cancer Science & Therapy