alexa Survival results of a multicentre phase II study to evaluate D2 gastrectomy for gastric cancer


Journal of Gastrointestinal Cancer and Stromal Tumors

Author(s): M Degiuli, M Sasako, A Ponti, F Calvo

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Curative resection is the treatment of choice for potentially curable gastric cancer. Two major Western studies in the 1990s failed to show a benefit from D2 dissection. They showed extremely high postoperative mortality after D2 dissection, and were criticised for the potential inadequacy of the pretrial training in the new technique of D2 dissection, prior to the phase III studies being initiated. The inclusion of pancreatectomy and splenectomy in D2 dissection was associated with increased morbidity and mortality. Following these results, we started a phase II trial to evaluate the safety and efficacy of pancreas-preserving D2 dissection. The results of this trial regarding the safety of pancreas preserving D2 dissection were published in 1998. In this paper, we present the survival results of this phase II trial to confirm the rationale of carrying out a phase III study comparing D1 vs D2 dissection for curable gastric cancer.

This article was published in British Journal of Cancer and referenced in Journal of Gastrointestinal Cancer and Stromal Tumors

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